date: 2021-08-24

transfusion products

content: coagulation factors, albumin, Igs, plasma proteins
indication: restore multiple coagulation factors (DIC)
FFP: frozen within 6 hours of collection, shelf life 1 year frozen, 24 hours after thawed, then has 5 days of storage
FFP: all soluble plasma proteins + clotting factors. Poor source of fibrinogen

content:
- when FFP thawed, small amount of plasma that precipitates
- fibrinogen, factor 8, factor 13, vWF
indication:
- mostly hypofibrinogenemia, such as DIC. Fibrinogen < 100 mg/d
- uremic bleeding
dosing: 5-10 units (from multiple donors pooled together)

content:
- platelet in plasma
- half life 5 days
dosing:
- platelet concentration: from whole blood donation
- platelets collected from aphresis: dosing equals 4-6u platelet concentrates, raises plt by 20-25k

plasma pooled from thousands of donors and fractionated into different derivatives:
- albumin
- Ig
- Rh Ig
- coagulation factor concentrates: factor 8
recombinant factor concentrates: not containing any donor plasma. Used for younger patients with hemophilia (factor 8 and 9)
Prothrombin complex concentrates (PCC):
- factor 2, 7, 9, 10
- preferred product for bleed while on warfarin
- only use for life threatening bleed because risk of thrombosis, do not just give for elevated INR
- carries residual heparin, CI in HIT
3 factor PCC: factor 2, 9, 10
4 factor PCC: 2, 7, 9, 10
Activated PCC (Feiba): factor 2, 7a, 9, 10

tranexamic acid (Lysteda): inhibits fibrinolysis by forming complex that displaces plasminogen from fibrin. Inhibits plasmin
aminocaproic acid (Amicar): binds competitively to plasminogen and blocks binding to fibrin