tpa contraindications in stroke

Contraindications to fibrinolysis with tPA include:

• Presence of active internal bleeding
• Bleeding diathesis (eg, platelets <100,000/µL)
• Hypodensity in >33% of an arterial territory on CT scan
• Presence of intracranial hemorrhage on CT scan
• Intracranial surgery in the last 3 months
• Blood pressure >185/110 mm Hg