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Phenytoin Toxicity
phenytoin toxicity
- related: pharmacology
- tags: #note
This patient's presentation suggests phenytoin toxicity. Early signs of toxicity include horizontal nystagmus and gait unsteadiness. These may be followed by slurred speech, lethargy, confusion, or even coma. Bradyarrhythmias and hypotension are usually seen with intravenous phenytoin. Toxicity can occur after dosage increase
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Medicine
Medicine
Todos
- tolearn
- MKSAP todos
- heart murmurs
Organ Systems
- Allergy and Immunology
- Rheumatology
- Cardiology
- Dermatology
- Endocrine
- ENT
- GI
- Hemeonc
- ID
- MSK
- Nephrology
- Urology
- Neurology
- Pulmonology
- Podiatry
Subject Areas
- General
- Biostats
- Psychiatry
- [[Geriatric
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SSRI Side Effects
SSRI side effects
- related: pharmacology
- tags: #note
This patient reports some improvement of his depression as well as new symptoms that are likely early side effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine (ie, nausea, anxiety, insomnia). Gastrointestinal and activating side effects are common at the start of SSRI treatment, and tolerance typically develops over several weeks. In contrast, SSRI-related sexual dysfunc
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Intranasal Steroids Can Cause Epistaxis
intranasal steroids can cause epistaxis
- related: pharmacology
Intranasal glucocorticoid sprays (eg, fluticasone, mometasone, budesonide) are the most effective agents for allergic rhinitis. Their anti-inflammatory effects may provide relief within hours, although chronic untreated symptoms may require several days or weeks of treatment for maximal improvement. Nasal saline rinses are also helpful as adjunctive therapy, as they hydrate the nasal mucosa and can
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Liposomal Amphotericin B
liposomal amphotericin B
- related: ID, pharmacology
Indicated for treatment of Aspergillus species, Candida species, and/or Cryptococcus species infections refractory to amphotericin B deoxycholate, or if renal impairment or unacceptable toxicity precludes use of amphotericin B deoxycholate
Liposomal formulations have been found to have less renal toxicity than deoxycholate,and fewer infusion-related reactions. They are more expensive than amphotericin B deoxyc
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Ciprofloxacin Side Effects
ciprofloxacin side effects
- related: pharmacology
- DM: wild glucose changes
- Long QTc
- tendinitis: tell patients to watch out for exercises
- Do not use IV if patient can take PO. Absorption profile is similar for both
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Vancomycin and Daptomycin
vancomycin and daptomycin
- related: pharmacology
Pros of daptomycin:
- No renal toxicity
- Once a day dosing
- No need to check levels
Cons of daptomycin:
- expensive
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Antibiotic Coverage
antibiotic coverage
- related: pharmacology
- every time abx prescribed, define the infection: Microbiologically Anatomically: structures involved Pathophysiologically: how infection got there
CAP
high dose amoxicililn: 1 gm TID or high dose doxycycline comorbidity: Augmentin: combine with another macrolide or doxy
Cep
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Amitriptyline and Metanephrine
amitriptyline and metanephrine
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related: pharmacology
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amitriptyline, venlafaxine, duloxetine, nortriptyline can cause falsely elevated normetanephrine levels
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can also occur with levodopa (substrate for catecholamine synethesis)
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can also occur with buspirone, prochlorperazine, amphetamines
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OTC decongestant
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can also be elevated in Amitriptyline can cause falsely elevated normetanephrine levels and should be discontinued prior to screening for pheochrom
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Fluoroquinolones Differences
fluoroquinolones differences
- related: pharmacology
- tags: #note
- moxi: lung, doesn't go to kidney
- cipro: kidney and lung
- levo: lung
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NMS vs Serotonin Syndrome
NMS vs serotonin syndrome
- related: Neurology, pharmacology
- tags: #note
This patient's presentation is consistent with serotonin syndrome, which presents as a triad with varying degrees of:- Mental status changes
- Autonomic hyperactivity, and
- Neuromuscular abnormalities
Gastrointestinal symptoms and diaphoresis are also common. This syndrome can occur after i
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Medicine
Todos
Organ Systems
- Allergy and Immunology
- Rheumatology
- Cardiology
- Dermatology
- Endocrine
- ENT
- GI
- Hemeonc
- ID
- MSK
- Nephrology
- Urology
- Neurology
- Pulmonology
- Podiatry
Subject Areas