Hemeonc

• Keywords:: Step 3, Medicine

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MKSAP

• management of bone metastasis
• Hematopoietic Stem Cells and Their Disorders
• Multiple Myeloma and Related Disorders
• Erythrocyte Disorders
• Iron Overload Syndromes
• Platelet Disorders
• MKSAP Bleeding Disorders
• MKSAP Transfusion Medicine
• Thrombotic Disorders
• Hematologic Issues in Pregnancy
• Issues in Oncology
• Breast Cancer
• Ovarian Cancer
• [[M

Transfusion Medicine

• related: Hemeonc

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• transfusion products
• transfusion goals
• transfusion reaction
• massive transfusion protocol

Transfusion Rate

hypocalcemia is common abnormality after massive transfusion

• related: Hemeonc, massive transfusion protocol
• tags: #hemeonc

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• blood products have citrate preservative that binds to endogenous calcium after transfusion, leading to hypocalcemia
• hypocalcemia can cause coagulopathy
• don't wait for hypocalcemia on labs. Aim for mildly elevated calcium levels in massive transfusion

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ibcc massive transfusion protocol

• related: massive transfusion protocol
• tags: #literature
• source: https://emcrit.org/ibcc/mtp/

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• resuscitate first before intubate to avoid hemodynamic collapse
• 1:1:1 ratio is pRBC, plt, FFP
• target fibrinogen > 100
• TXA can be beneficial in massive transfusion
• avoid acedemia and hypothermia in transfusion
• target low normal MAP 60 to avoid bleeding

icu lecture coagulopathy and bleeding

• related: ICU, massive transfusion protocol
• tags: #icu

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Definition

• Coagulation: bleeding when you should; clotting when you should; no more and no less
• Coagulopathy: bleeding when you should not; clotting when you should not; more than less

Intrinsic and extrinsic pathway do not exist in real life. Real life is more complex

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