Fibromyalgia vs Polymyositis vs Polymyalgia Rheumatica

fibromyalgia vs polymyositis vs polymyalgia rheumatica

Ddx
	Clinical features	Diagnosis
Fibromyalgia	Young to middle-aged womenChronic widespread pain Fatigue, impaired concentration Tenderness at trigger points (eg, mid trapezius, costochondral junction)	>3 months of symptoms with widespread pain index or symptom severity score Normal laboratory studies
Polymyositis	Proximal muscle weakness (eg, increasing difficulty climbing up stairs) Pain mild/absent	Elevated muscle enzymes (eg, creatine kinase, aldolase, AST) Autoantibodies (ANA, anti-Jo-1) Biopsy: Endomysial infiltrate, patchy necrosis
Polymyalgia rheumatica	Age >50 Systemic signs & symptoms Stiffness > pain in shoulders, hip girdle, neck Association with giant cell (temporal) arteritis	Elevated ESR, C-reactive protein Rapid improvement with glucocorticoids

Ddx

Clinical features

Diagnosis

Fibromyalgia

Young to middle-aged womenChronic widespread pain
Fatigue, impaired concentration
Tenderness at trigger points (eg, mid trapezius, costochondral junction)

>3 months of symptoms with widespread pain index or symptom severity score
Normal laboratory studies

Polymyositis

Proximal muscle weakness (eg, increasing difficulty climbing up stairs)
Pain mild/absent

Elevated muscle enzymes (eg, creatine kinase, aldolase, AST)
Autoantibodies (ANA, anti-Jo-1)
Biopsy: Endomysial infiltrate, patchy necrosis

Polymyalgia rheumatica

Age >50
Systemic signs & symptoms
Stiffness > pain in shoulders, hip girdle, neck
Association with giant cell (temporal) arteritis

Elevated ESR, C-reactive protein
Rapid improvement with glucocorticoids

Polymyositis: Involvement of upper esophageal musculature can cause dysphagia with regurgitation and aspiration. Initial remission can be induced with glucocorticoids (eg, prednisone), and most patients also receive a glucocorticoid-sparing agent (eg, methotrexate, azathioprine) to minimize the long-term adverse effects of treatment.

Allergy and Immunology
Allergy and Immunology
- Keywords: Medicine
Immune deficiencies
- IgA deficiency
Soft tissue problems
Allergic Reactions
- transfusion reaction
Lupus
- 03 Resources/Medicine/Lupus
- mixed cryoglobulinemia
Myopathy
Myopathy Ddx
myopathy ddx
- Keywords:: Step 3, Allergy and Immunology
Myopathy occurs in approximately one-third of patients with hypothyroidism and can range from an asymptomatic elevation in CK to myalgias, muscle hypertrophy, proximal myopathy, and rhabdomyolysis. Serum CK can be
Polymyalgia Rheumatica
polymyalgia rheumatica
- Related: Step 3, Allergy and Immunology, fibromyalgia vs polymyositis vs polymyalgia rheumatica
- tags: #rheumatology
Polymyalgia rheumatica is an autoimmune disease with several sites of muscle and joint pain and it is commonly associated with temporal arteritis.

Polymyalgia rheumatica is more common in:
- Women
- People of northern European descent (i.e., Scandinavian countries)
- **The elderly (peak incide

Allergy and Immunology

Immune deficiencies

Soft tissue problems

Allergic Reactions

Lupus

Myopathy

myopathy ddx

polymyalgia rheumatica