euthyroid sick syndrome
- related: Endocrine
- aka nonthyroidal illness syndrome (NTIS)
- demographics: hospitalized and critically ill patients
- pathogenesis: illness suppress thyrotropin releasing hormone
- labs
- suppressed but detectable TSH
- undetectable TSH is not NTIS
- Can sometimes have elevated TSH but not > 20 mU/L
- T4 usually normal
- T3 lower than normal due to decreased deiodinase activity
- reverse T3 increases but biologically inactive
- TBG decreases, lowering total T4 and T3 levels
- Treatment
- Do not need to treat with levothyroxine
- Recheck TSH 6 weeks after illness
Backlinks