Mastalgia (breast pain) is a common and benign symptom that most women experience due to estrogen and progesterone changes associated with the menstrual cycle. The pain is often cyclic, beginning up to 2 weeks before menses and usually subsiding by the onset of menses; it is typically described as heavy, diffuse, dull, and bilateral. Generalized swelling and mildly tender nodularity may be present, but there are no discrete masses or nipple discharge.
Symptomatic relief can be achieved by wearing a properly fitted bra with good breast support that minimizes breast movement. Acetaminophen or nonsteroidal anti-inflammatory drugs (eg, ibuprofen) can also be administered for pain relief. In addition, danazol is currently approved by the Food and Drug Administration for mastalgia; however, it may cause permanent androgenic side effects (eg, hirsutism) and increases the risk of thromboembolism.