Vasculitis
![](https://i.imgur.com/56HM9OE.jpg)
- very rare in real life
- organ specific symptoms because vessel lumen occludes
![](https://i.imgur.com/reeeL9a.jpg)
![](https://i.imgur.com/hMT7V9M.jpg)
- increase blood flow or hyperemia: blanch when pressed
![](https://i.imgur.com/JP2y4AN.jpg)
- see palpable purpura = vasculitis
![](https://i.imgur.com/7MbLPWt.jpg)
Large Vessel
![](https://i.imgur.com/Pxc50XZ.jpg)
Temporal Arteritis
![](https://i.imgur.com/vGa1NNL.jpg)
- face and head symptoms
- ophthalmic artery from internal carotid
![](https://i.imgur.com/3iQCCT1.jpg)
- High ESR: classic
- granuloma
- high IL6
Takayasu
![](https://i.imgur.com/ECwR2Nh.jpg)
![](https://i.imgur.com/TiIOTii.jpg)
- picture: narrowing of left subclavian artery
- weak upper extremity pulse
- cold/numb fingers
- granuloma on histology
Medium Vessel
Kawasaki
![](https://i.imgur.com/rn2pTV6.jpg)
![](https://i.imgur.com/xJab6mq.jpg)
![](https://i.imgur.com/G4ke6Lz.jpg)
- acute: 1st 2 weeks, fever, arthritis, myocarditis, rash
- subacute: skin falls off, aneurysm
Scarlet
![](https://i.imgur.com/S8OgeXa.jpg)
- scarlet fever: sore throat
Reye
![](https://i.imgur.com/jlE8tdY.jpg)
Buerger
![](https://i.imgur.com/7Tacug7.jpg)
- aka thromboangiitis obliterans
- male smokers. Almost never in nonsmokers
- segmental thrombosing vasculitis: blood clots cut off blood to hands/feet
- distal claudication and ulcers
- characterized histologically by intraluminal thrombus and prominent inflammatory cell infiltrate with relative sparing of the vessel wall.
PAN
![](https://i.imgur.com/AGuZIyR.jpg)
- deposit in many places, wide variety of symptoms
![](https://i.imgur.com/pT6moco.jpg)
![](https://i.imgur.com/0eBRORj.jpg)
![](https://i.imgur.com/lvqxO7v.jpg)
- ischemia and renal failure
Small vessels
HS purpura
![](https://i.imgur.com/J9Gde87.jpg)
- complement activated via alternative/lectin pathway. IgA does not fix complement
![](https://i.imgur.com/CGrChh6.jpg)
![](https://i.imgur.com/4Ax7SN3.jpg)
- biopsy shows IgA deposition
ANCA
![](https://i.imgur.com/xmB2yZO.jpg)
- pulmonary different for each; renal similar for all 3
- lower right: negative IF, no Ig
![](https://i.imgur.com/KtbIDBx.jpg)
Churg Strauss
![](https://i.imgur.com/YwLBcAC.jpg)
- looks like asthma as adule first time refractory to medical therapy
- classic case: adult onset asthma with palpable purpura, eosinophila, p-ANCA
Wegener
![](https://i.imgur.com/R7azSd4.jpg)
- saddle nose due to ulcers
Microscopic polyangitis
![](https://i.imgur.com/J76rqWV.jpg)
Goodpasture
![](https://i.imgur.com/bmQaFu9.jpg)
![](https://i.imgur.com/YotdR9h.jpg)
![](https://i.imgur.com/DrCUb0K.jpg)
![](https://i.imgur.com/cI1Z6Wm.jpg)
Backlinks