Immunosuppressants

• autoimmune disease, RA, transplant rejection

Cyclosporine, Tacrolimus

• calcineurin normally activates NFAT via dephosphorylation
• decreased IL2

• histology: tubule vacuolization
• Diltiazem inhibitor of P450

• usually with phenytoin

Sirolimus

Methotrexate

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• leucovorin rescue: done in a cycle with methotrexate

Mycophenolic Acid

• B and T cell only

Cyclophosphamide

Azathioprine

• salvages hypoxanthine and guanine to make new nucleotides

• mutant nucleotide, toxic to cells

Muromonab

• CD3 surface marker, carry signal inside

• initially activate T cells during 1st or second dose
• cytokines flooding from T cells

Infliximab

• TNF binds Etanercept instead of TNF receptor

Malaria

• raise pH of lysosomes