Cell Cycle

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• G1: first growth phase
• S: synthesize DNA
• M: mitosis
• G0: Quiescent phase
• M: mitosis (dividing) and I: interphase (not dividing)

• growth factor: grow in size
• mitogen: grow by division

• mitotic spindle: fibers and microtubules

• sister chromatids pulled to opposite ends

Cell Cycle Control

• within M phase
• first checkpoint very important: decision to commit growth

• cyclin D/CDK4 and 6, and cyclin E/CDK2
• RB and DNA damage checkpoint

• P53 easily falls apart, unless DNA damage, then easily stabilized and induce p21

Pathology