COPD clinical trials

• related: COPD, Pulmonology
• tags: #pulmonology

Resting O2

• Lancet 1981
• resting O2 reduces mortality for pts with resting hypoxemia spO2<88
• LOTT trial 2016: no decrease in time to death or time to hospitalization

Uplift

• UPLIFT 2008
• tiotopium relieves dyspnea, improves lung function, quality of life, reduces exacerbation
• no significant difference in FEV1 decline or mortality

Torch

• TORCH 2007
• ICS/LABA improved lung function with FEV1 vs placebo vs LABA vs ICS
• no mortality benefit with combination therapy

React

• REACT 2015
• triple therapy with Roflumulast (long acting PDE4 inhibitor)
• population: severe COPD, chronic bronchitis, and at least 2 exacerbations
• significant reduction in exacerbations
• increased side effects: diarrhea, nausea, decreased appetite

Albert

• Albert 2011
• Chronic azithromycin
• population: pts with mod-severe COPD and either continuous O2 or at least on exacerbation in last year