26 Renal Tumors
- 1st 3 kidney cancer, RCC most common
- last 3 bladder cancer, transitional most common
RCC
- cigarette and obesity very important
- few pts have classic triad, most just have hematuria
- glycogen/lipids do not stain very well
- N: normal
- circle: yellow mass
- F: fat
- IL 2 part of inflammatory response, like giving flu to someone
- Plush cancer crab in kidney machine: interferon alpha treats renal cell carcinoma
Wilm's
- HTN in children very rare
- average age 3
- tumor in child kidney, think Wilm's
- composed of blastema: primitive kidney tissue
- large unilateral flank mass
- neonatal hypoglycemia
- large tongue
Angiomyolipoma
- angio: blood vessel; myo: smooth muscle; lipoma: fat
- cortical tuber: growth or bulge
- very important: leaf-like patches of skin, pale skin in shape of leaf
- Lack of migration
- Neocortical tubers: very hard and white. Glia and neurons jumbled up
- Nodules around ventricles
- Brain tumors SEGA
- top: discolored areas
- SEGA: blocking fluid in ventricles = hydrocephalus. Tube to drain extra fluid
- don't worry about histology.
- Big mass in child
- Looks like fat in middle of kidney
Transitional Cell Carcinoma
- flat pathway: high grade flat tumor then invades. Early p53 mutation
- papillary: low grade papillary tumor that progress to high grade and then invade. Not association with p53
- smoker with hematuria: think bladder cancer
- phenacetin: analgesic
- any industrial job
- Cancer crab belt buckle: cyclophosphamide increases risk of bladder cancer (high grade transitional cell carcinoma)
- cast: glomerular source of bleeding
- platinum used for transitional
Squamous Cell
Adenocarcinoma
Backlinks