18 Nephrotic Syndrome

• may be in casts or in plasma membranes

• mostly LDL not HDL

• diseases damage podocytes leads to nephrotic syndrome
• podocytes walled off from cellular components, no inflammation, no nephritic

Minimal Change Disease

• loss of albumin (-) in urine
• HL: massive production of cytokines

• things trigger cytokines can trigger MCD

• steroids help cytokines
• most other nephrotics not responsive to steroids

• minimal changes on renal biopsy

FSGS

• more serious/dangerous version of MCD

• HIV associated

• IgM, C3

• image: normal upright, abnormal lower left; pink deposition in abnormal

Membranous Nephropathy

• no triggering inflammation

• thick knots in string: Associated with membranous glomerulonephritis
• 3 string: Associated with membranoproliferative glomerulonephritis. Tram track appearance

• if hypercellular: membranoproliferative

• thick GBM

• Spike and Dome

Diabetic Nephropathy

Amyloidosis