18 Hodgkin Lymphoma
![](https://photos.thisispiggy.com/file/wikiFiles/Nb7mrOD.jpg)
- lymphocytes form mass: oma
![](https://photos.thisispiggy.com/file/wikiFiles/dmc5qBB.jpg)
- painful: reactive lymph nodes in infection
![](https://photos.thisispiggy.com/file/wikiFiles/9UDrb6j.jpg)
- tissue biopsy of mass/lymph node
Reed-Sternberg
![](https://photos.thisispiggy.com/file/wikiFiles/iD6MBss.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/AFlnjVQ.jpg)
Hodgkin Lymphoma
![](https://photos.thisispiggy.com/file/wikiFiles/hRLny7Q.jpg)
- autoimmune: immune activation
![](https://photos.thisispiggy.com/file/wikiFiles/f98eyJq.jpg)
- Owl sitting in weeds: Hodgkin lymphoma = Reed-Sternberg cells that look like "owl's eyes"
![](https://photos.thisispiggy.com/file/wikiFiles/pHAMAfE.jpg)
- reed sternberg only a small amt of cell in lymph nodes
- most cells are reactive cells reacting to cytokines from reed sternberg: B symptoms more common
- one of the reactive cells: macrophages, containing 1a hydroxylase
![](https://photos.thisispiggy.com/file/wikiFiles/jfhFv17.jpg)
- spread from 1 set of nodes to another, very predictable
![](https://photos.thisispiggy.com/file/wikiFiles/HuYNznP.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/utlga7u.jpg)
- variant of reed sternberg: popcorn cells
![](https://photos.thisispiggy.com/file/wikiFiles/s5mIZXF.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/bdM3v96.jpg)
- tumor forms fibrosis tissues that surrounds tumor, creating nodules
![](https://photos.thisispiggy.com/file/wikiFiles/bbABbrX.jpg)
- mixed cellularity: lots of eosinophils
- more the lymphocytes, better prognosis
![](https://photos.thisispiggy.com/file/wikiFiles/EYm4TLQ.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/hQ1MO35.jpg)
- enlargement often in nonhodgkin
![](https://photos.thisispiggy.com/file/wikiFiles/TXWA5YF.jpg)
- most common regimen
- don't memorize
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