17 Chronic Leukemia
![](https://photos.thisispiggy.com/file/wikiFiles/XV1Bgit.jpg)
- granulocytes: CML, leukemia since WBC
![](https://photos.thisispiggy.com/file/wikiFiles/40mlYAf.jpg)
- leukemia: increased WBC in blood
- myeloproliferative disorder: over proliferation of cells
![](https://photos.thisispiggy.com/file/wikiFiles/plLX9DY.jpg)
- nl WBC 10k
- increase in every stage of neutrophils
- RBC low
![](https://photos.thisispiggy.com/file/wikiFiles/yqe1HV8.jpg)
- number of phases
- chronic: nonspecific phase
![](https://photos.thisispiggy.com/file/wikiFiles/VQRVJIY.jpg)
- important to distinguish AML from left shift
- must exclude left shift to diagnose CML
![](https://photos.thisispiggy.com/file/wikiFiles/79bFjl7.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/FHHFXEF.jpg)
- BCL from 9 and ABL from 22
- translocation: BCL-ABL next to each other on 22
![](https://photos.thisispiggy.com/file/wikiFiles/s4KFG8J.jpg)
CLL
![](https://photos.thisispiggy.com/file/wikiFiles/0KAsnGN.jpg)
- naive lymphocytes not lymphoblasts
- CD5: T cell marker
- CLL: a confused malignancy, not sure if it wants to be leukemia or lymphoma
![](https://photos.thisispiggy.com/file/wikiFiles/Buo3apt.jpg)
- can have large lymph nodes like SLL
![](https://photos.thisispiggy.com/file/wikiFiles/GlgrjDs.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/Y3hClyT.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/VRblUTT.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/Wk0YGee.jpg)
- related to CLL
- CLL, leukemia: high WBC
- SLL, lymphoma: swollen lymph nodes with mild lymphocytosis
Hairy Cell
![](https://photos.thisispiggy.com/file/wikiFiles/3GmDTFh.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/hwPAYxh.jpg)
- WBC fill up red pulp so big that obliterates white pulp
![](https://photos.thisispiggy.com/file/wikiFiles/LO2Unts.jpg)
- abd pain from splenomegaly
![](https://photos.thisispiggy.com/file/wikiFiles/oQQSrMz.jpg)
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