17 Chronic Leukemia
- granulocytes: CML, leukemia since WBC
- leukemia: increased WBC in blood
- myeloproliferative disorder: over proliferation of cells
- nl WBC 10k
- increase in every stage of neutrophils
- RBC low
- number of phases
- chronic: nonspecific phase
- important to distinguish AML from left shift
- must exclude left shift to diagnose CML
- BCL from 9 and ABL from 22
- translocation: BCL-ABL next to each other on 22
CLL
- naive lymphocytes not lymphoblasts
- CD5: T cell marker
- CLL: a confused malignancy, not sure if it wants to be leukemia or lymphoma
- can have large lymph nodes like SLL
- related to CLL
- CLL, leukemia: high WBC
- SLL, lymphoma: swollen lymph nodes with mild lymphocytosis
Hairy Cell
- WBC fill up red pulp so big that obliterates white pulp
- abd pain from splenomegaly
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