13 FA
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Synthesis
- acetyl coa can be used for FA synthesis but can't cross membrane
- citrate also inhibit glycolysis once in cytosol
- malonyl coa inhibit beta oxidation so no breakdown of FA while synthesis
Breakdown
Glycerol
- glycerol travel to liver and converted to glycerol-3-phosphate
FA
- increased requirements from high metabolism
- can't breakdown FA
- cardiomyopathy: heart also needs FA
- can only use glucose: hypoglycemia
- cannot make ketones
- normally hypoglycemic = high levels of ketone bodies
- can't move carnitine
- has carnitine
- build up of FA
- high levels of acyl carnitine
- dicarboxylic acids made via omega oxidation
- even chain: metabolize until gone
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