12 ETC

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• takes electrons from electron carriers

• 2 NADH outside have to be shuttled in via malate shuttle or glycerol phosphate shuttle

• mitochondria membrane convert glycerol phosphate back and generate FADH2, carry not as much energy. Some energy lost

Complex 1

• ski.jpg II

Complex II

• CoQ deliver enzymes to complex 3

Complex III

• iron goes back and forth in cytochrome as opposed of Hgb

• oxidizes cytochrome c

• phosphorylating ADP to make ATP via enzyme

• ATP synthase complex 5

• number of ATP generated per O2

Poisons

• uncoupling: ETC still working but not coupled to phosphorylation of ADP

• rotenone: inhibitor of reduction of CoQ
• CO binds Fe2 and competes with O2 for electron transfer
• cyanide no effect on RBC with Fe2

• progress to shock quickly
• O2 not extracted because ETC inhibited
• lactic acidosis: one of ways people die

• poke a hole in inner membrane

• DNP in research labs
• aspirin: fever, H+ leaking out generating heat
• normally lipolysis makes ATP
• brown fat: not coupled ETC, lipolysis generates heat