11 TCA

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• products used where they are produced

• acetyl coa donates 2 C to TCA that are removed as 2 CO2, no net difference in carbons
• acetyl coa cannot be converted to glucose that's made from oxaloacetate because it doesn't donate any extra carbons
• even chain FA can be converted to acetyl coa, cannot increase oxaloacetate or make glucose

Citrate

• irreversible, regulated by ATP
• citrate important indicator of energy levels inside cell. High levels of ATP inhibits citrate metabolism

• lowers level of oxaloactate for citrate synthase = less acetyl coa used
• high acetyl coa also from FA oxidation
• result: shunted towards ketone

Isocitrate

A Ketoglutarate

Succinyl

• irreversible
• succinyl coa/NADH inhibit

Succinate

Fumarate

Malate

• transport NADH in for ETC and oxaloacetate out for gluconeogenesis

• donate electron from NADH to malate
• OAA regenerated outside via aspartate conversion