11 RTA
![](https://photos.thisispiggy.com/file/wikiFiles/RmY3lYb.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/ZdfxBrc.jpg)
- many times asymptomatic, discovered on routine blood work
- changes bicarb level: non-anion gap
Type 1
![](https://photos.thisispiggy.com/file/wikiFiles/9ZGVm9H.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/Yz66nJr.jpg)
- H channel defect, can't secrete H
- K held in lumen, no absorption
![](https://photos.thisispiggy.com/file/wikiFiles/Eq5v6gE.jpg)
- in metabolic acidosis, urine should be low to excrete H
- if high pH, there's defect excreting H
![](https://photos.thisispiggy.com/file/wikiFiles/Z0RgZ6E.jpg)
- bilateral stones: think distal RTA
Calcium binds to negative albumin, competing with hydrogen ions
- Alkalosis: less H+ competing, more Ca binding, which decreases free calcium levels.
- Acidosis, increase H+ competing, less Ca binding, resulting in increased free calcium levels
![](https://photos.thisispiggy.com/file/wikiFiles/4wT4J5w.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/TfwGhDd.jpg)
- very very high yield: sjogren or RA
![](https://photos.thisispiggy.com/file/wikiFiles/kany643.jpg)
- 1 shaped acid tube: renal tubular acidosis (RTA) type 1 is cumulative toxicity of amphotericin
- Depleted potassium banana peel: RTA type 1 is associated with hypokalemia
Urine Anion Gap
![](https://photos.thisispiggy.com/file/wikiFiles/opgrQhq.jpg)
- urinary anion gap equation different from plasma anion gap
- urine Cl goes up, UAG becomes negative
![](https://photos.thisispiggy.com/file/wikiFiles/qROcXL5.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/Og2JlDc.jpg)
Type 2
![](https://photos.thisispiggy.com/file/wikiFiles/5DXD8HZ.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/TGRX0Xu.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/c7tJih7.jpg)
- Fan cone: Fanconi syndrome (type 2 RTA) associated with use of expired tetracyclines
![](https://photos.thisispiggy.com/file/wikiFiles/uVUbGWQ.jpg)
Type 4
![](https://photos.thisispiggy.com/file/wikiFiles/zVDmi0L.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/74tSnO9.jpg)
- aldosterone doesn't work > hyperkalemia
- hyperkalemia > increased K into cell, increased H out of cell> high pH in PCT cells
- high pH > unable to excrete H and NH3
- Inadequate amount of NH3 available for buffering of protons. Even if only a few protons are secreted distally, urinary pH will fall in the absence of buffers.
![](https://photos.thisispiggy.com/file/wikiFiles/e577TwD.jpg)
- diabetic renal: less renin production from renal insufficiency
- ace/ARB: less aldosterone
- bactrim: disrupt K excretion
- Hyperkalemic RTA is commonly seen in elderly patients who have poorly controlled diabetes with damage to the juxtaglomerular apparatus, which causes a state of hyporeninemic hypoaldosteronism.
![](https://photos.thisispiggy.com/file/wikiFiles/JbCySDz.jpg)
- ACE I: high potassium cup
![](https://i.imgur.com/t7MSOYP.jpg)
- Depleted mineral mine: NSAIDs can cause hypoaldosteronism (decreased mineralocorticoids)
- Big K: NSAID induced hypoaldosteronism can cause hyperkalemia. Type 4 RTA
![](https://photos.thisispiggy.com/file/wikiFiles/5XGsQLW.jpg)
- Mad scientist with 4 tubes of acid: Type IV renal tubular acidosis (RTA)
- K shape: Type IV RTA leads to hyperkalemia
![](https://photos.thisispiggy.com/file/wikiFiles/e65ouNz.jpg)
- Elevated bananas: K+ sparing diuretics can cause hyperkalemia
- Acid spill into intracellular space: K+ sparing diuretics cause a normal anion gap metabolic acidosis (by decreasing the function of the H+ATPase)
- 4 acid tubes: K+ sparing diuretics inhibit the effects of aldosterone in the collecting duct causing a type 4 renal tubular acidosis (RTA)
- Big K: type 4 RTA is associated with hyperkalemia
![](https://i.imgur.com/SOQB1Z3.jpg)
- Depleted mineral mine: heparin can cause hypoaldosteronism (a mineralocorticoid)
- Big K: heparin induced hypoaldosteronism (Type 4 RTA) causes hyperkalemia
![](https://photos.thisispiggy.com/file/wikiFiles/mO7ZAnH.jpg)
- fludrocortisone: synthetic aldosterone
![](https://photos.thisispiggy.com/file/wikiFiles/bEXRioq.jpg)