10 Pyruvate Dehydrogenase
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![](https://photos.thisispiggy.com/file/wikiFiles/75559CA9-5BB9-4A30-920D-2918BFAE9CAE.jpg)
- pyruvate dehydrogenase to acetyl coa to TCA
- lactate: RBC without mitochondria and muscles. Muscles release lactate to blood to go back to liver
- alanine: alanine carry nitrogen to liver, extract nitrogen to urea
- must enter mitochondria for gluconeogenesis and acetyl coa
![](https://photos.thisispiggy.com/file/wikiFiles/26691759-623F-4371-B5B4-1E81509F1003.jpg)
- 1st step for gluconeogenesis in mito
- outer: just a pore
![](https://photos.thisispiggy.com/file/wikiFiles/C43F5C0A-AECB-4ABC-A378-29C540F57A38.jpg)
- once inside mito
- high ATP, slow TCA, high Acetyl- coa and activates pyruvate carboxylase, preferential shunt towards gluconeogenesis
- acetyl coa also inactivates pyruvate dehydrogenase
![](https://photos.thisispiggy.com/file/wikiFiles/25E4BE3D-E727-419B-996A-D70D58E517BC.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/7DE2E809-32D1-436B-8BC6-A37211E31C39.jpg)
- E1 adds thiamine PP to pyruvate and release CO2
- E3 keeps lipoic acid in proper form
Thiamine
![](https://photos.thisispiggy.com/file/wikiFiles/1534C18D-4D9C-4236-9316-D43B95DA5E2D.jpg)
- TPP active form, 2 phosphates from ATP
![](https://photos.thisispiggy.com/file/wikiFiles/594077C2-917A-43E5-8150-8BD0AA49727A.jpg)
- thiamine deficient, cannot convert pyruvate to acetyl-coa, no ATP
![](https://photos.thisispiggy.com/file/wikiFiles/7BA1B5DA-2240-411B-B21C-196E9909DE64.jpg)
FAD
![](https://photos.thisispiggy.com/file/wikiFiles/CB03EAAF-F11F-43FF-88D5-D31B23C71A9A.jpg)
- used in oxidative phosphorylation
NAD
![](https://photos.thisispiggy.com/file/wikiFiles/952DCA16-B665-4EC0-A771-65C3A3174B16.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/7F77A7FD-E690-47A8-89DE-A4FA77477EC9.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/E53B2516-8588-4810-811D-51F5944D3036.jpg)
- first 4 all used in pyruvate dehydrogenase complexes
Lipoic
![](https://photos.thisispiggy.com/file/wikiFiles/B2E36A43-2191-447A-87E8-26637AC91DE4.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/0A5643A1-CE4E-4054-98BA-9DBD8B715A6D.jpg)
- Ca activator in skeletal muscles when exercising
![](https://photos.thisispiggy.com/file/wikiFiles/F0888BF8-8214-49B5-AC29-A23D20037B05.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/11017CB6-FED4-46FD-8306-9635CA432DE9.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/870E81C3-A3AB-48F8-B6E5-07ABA123F215.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/609D33BB-397E-42D5-BDF3-6B323DF8113C.jpg)
- whenever pyruvate not metabolized, build up in mito and shunted towards lactate
![](https://photos.thisispiggy.com/file/wikiFiles/CD8B4634-75B3-4F39-A62B-0C0403821D48.jpg)
- fat converted to acetyl coa without going through pyruvate
![](https://photos.thisispiggy.com/file/wikiFiles/9E9FDCA5-E8DC-4CF7-9F88-D12E4E141016.jpg)
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