08 HMP Shunt

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• offshoot of glycolysis

Pathway

• not in mitochondria
• oxidative: G6P to R5P
• reductive: R5P to F6P and G6P

Oxidative

• CO2 removed to go from 6C to 5C

Reductive

R5P

NADPH

• NADH very different function from NADPH
• not used to generate ATP

• donate electron to other molecules, reducing them

Phagocytosis

• uses NADPH from HMP shunt

Oxidative Damage Protection

• glutathione protects RBC from oxidative damage

• bite cells: spleen try to remove heinz bodies