08 Bone Biology
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- trabeculated: honey combed
- center: medullary cavity
- top: porous, trabeculated, end of long bone
- osteoclast slave to osteoblast
Formation
- 2 ossifications grow towards each other and trap epiphyseal plate
- layer of cartilage trapped = growth plate
- chondrocytes grow toward epiphysis
- osteoblast grow towards diaphysis
- woven bone remodeled by osteoblast
- Hunter's and Hurler's cannot metabolize mucopolyssachrides
- all these go up in increased activity
- acidosis bad for bone formation
- chronic acidosis: bone break down
