05 Pharmacokinetics
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- method apply drug affect how much bioavailable
- percent to blood stream
- compare area under curve for oral with area under curve for IV
- 1st steep decline: reaching steady state in body
- C0: concentration if drug immediately distribute equally in body
- large/charged: can't leave vascular compartment
- chloroquine: large amount in tissue, little in blood stream. Back calculation = large number
- greater effects/SE when more unbound drug move to tissues
- metabolized/excreted faster
- elimination constant: how quickly kidney clears a volume of plasma
- greater the volume of distribution, greater the clearance (remove same number of molecules but in more plasma)
- clearance not amount of drug held by kidney but amount of volume cleared of drug
- higher the clearance, higher elimination constant
- 4 half lives to get drug out of body
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