05 Pedigree

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• affecting both male/female
• most people don't have disease
• middle: both people don't have disease but are carriers

AD

• males/females affected
• 50% offspring have disease
• male to male transmission occurs (pass Y), not X linked

X linked

• one of X becomes inactive

• different cells in females will have different lyonization
• skewed lyonization: more healthy X become lyonized

X Dominant

Mitochondrial

• confusion from CNS effects
• lactic acidosis from no aerobic metabolism

Polygenetic