05 Glycolysis
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- red arrows: nonreversible
Hexokinase/Glucokinase
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- G6P traps glucose inside cell
- once high levels of G6P, stop: doesn't hoard glucose
![](https://photos.thisispiggy.com/file/wikiFiles/8145CDFC-F0B4-41B0-B520-B27304739E7A.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/41842CE1-E93F-4C0A-989D-93C2275FC84B.jpg)
- anytime glucose level high, it is taken up and converted to G6P
- only time G6P inactive is low glucose and high F6P = fasting and gluconeogenesis
![](https://photos.thisispiggy.com/file/wikiFiles/41638AB3-4CE1-4411-A4DC-406B11A47C82.jpg)
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- from cytosol to nucleus = inactive
- G6P will always be active in high glucose state, regardless of F6P
![](https://photos.thisispiggy.com/file/wikiFiles/20C8142E-4D45-426A-8CF1-D6D085EC994D.jpg)
Glucokinase Deficiency
![](https://photos.thisispiggy.com/file/wikiFiles/3071ACB7-E70E-44C9-BD3E-C9EE180B9E9A.jpg)
- won't release insulin and won't take up glucose
PFK 1
![](https://photos.thisispiggy.com/file/wikiFiles/4CFCB2EE-830D-4949-BE7D-7FE3F03C88F7.jpg)
- committed step
- all the way to pyruvate
![](https://photos.thisispiggy.com/file/wikiFiles/E1B7B3D4-31D8-465E-A1B1-F474D4373F35.jpg)
- F26BP: way insulin controls glycolysis
F26BP
![](https://photos.thisispiggy.com/file/wikiFiles/A35AA17E-2E3C-43F8-9837-6E11F3A19552.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/4B75112F-D16B-4F9D-AF22-86E9124D3311.jpg)
- glucagon leads to phosphorylation of PFK2/PBPase2
![](https://photos.thisispiggy.com/file/wikiFiles/5C3EAEB6-79A7-4F0B-85E9-274FAFE2AE5C.jpg)
- insulin dephosphorylates PFK2, activating it
- insulin dephosphorylates F26BP, inactivating it
![](https://photos.thisispiggy.com/file/wikiFiles/34C169B3-B95C-43F2-847C-0C476A51C7D3.jpg)
Splitting
![](https://photos.thisispiggy.com/file/wikiFiles/19F7DBE6-5F79-488B-9E88-CAB0CC8AAA75.jpg)
Energy Stage
![](https://photos.thisispiggy.com/file/wikiFiles/CCF9CDA8-4A20-4D01-B54E-24A2014288AF.jpg)
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- alanine byproduct of degradation of protein
- liver sees alanine, inhibit pyruvate kinase and glycolysis to not use glucose
![](https://photos.thisispiggy.com/file/wikiFiles/D88AB87C-92BA-4367-915B-05FC92D169D5.jpg)
![](https://photos.thisispiggy.com/file/wikiFiles/BBD5637D-7D83-495F-AEB7-331A319E13B3.jpg)
- regenerates NAD+ after use of 1st step to keep conducting glycolysis
![](https://photos.thisispiggy.com/file/wikiFiles/AA139F79-EA4A-4238-AE9F-B5C6984C33F9.jpg)
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