04 Virus Structure
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- glycoproteins for attachments
Capsid
- both made by multiple identical copies of proteins
Envelopes
- icosahedral shape very stable. If not envelope = icosahedral shape
- envelope virus can't survive in environment, not transmitted fecal oral or contaminated water
- Hep B/Herpes/HIV all transmitted directly
RNA
- host cell synthesize proteins using +RNA
- top: + RNA, synthesize directly to proteins
- middle: -RNA, nucleic acid not make sense, can't be translated
- RNA polymerase flip 3' and 5' end and also flip the bases
- no human enzyme available to make RNA from RNA
+RNA
- RNA in cell, immediately translated
- one of translated is RNA polymerase that makes - RNA and also translate - RNA to + RNA genome
-RNA
- positive intermediate RNA translated and made into -RNA genome
Retro
DNA
Infectivity
- whether or not nuclear material can cause infection by themselves
Segmented
- papilloma, polyoma, hepadna all have circular DNA
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