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Step 1
04 Complement
great for encapsulated bacteria
C3
Overview of complement
3 different pathways, next step always MAC
Alternative Pathway
destroyed in less than a second if not bound
C3b
stable c3b creates more of itself via positive loop
Factor H
Lectin Pathway
Classical pathway
Alternative and MBL part of innate immunity
C1
IgM: 2 Fc very close together, easy C1 binding
IgG: ok complement activation
CRP
binds C polysaccharides of bacteria
C3a C3b
MAC
aka late complement
C5a
Inhibition
PNH
DAF/CD59 deficiency
start at RBC lysis
Free plasma Hgb thrombogenic
Priapism: sustained prolonged erection
C3 Deficiency
immune complex: antigen-antibody, usually cleared via complement binding and macrophage
C5-9 deficiency
not as bad as c3 deficient
Hereditary Angioedema
c1 inhibitor breaks down bradykinin
urticaria: histamine, not here
Epinephrine doesn't work
ace inhibitor block bradykinin breakdown
C3 Nephritic
Hypocomplementemia
CH50: classic pathway lysis sheep RBC. Qualitative test, yes or no
C3b
Factor H
C1
CRP
C5a
PNH
C3 Deficiency
C5-9 deficiency
Hereditary Angioedema
C3 Nephritic
Hypocomplementemia
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Step 1 Immunology
step 1 Immunology
related:
Step 1
01 Innate Immunity
02 T Cells
03 B Cells
04 Complement
05 Spleen
Antibodies
Glucocorticoids
Hypersensitivity
Immune Deficiencies
Immunosuppressants
Lupus
Scleroderma BB
Sjogren
Step 1 Rheumatoid Arthritis
Transplants
Vasculitis