03 Bacteria Virulence

Protein A

.

IgA Protease

M Protein

• Prevents phagocytosis.

.

Endotoxin

• LPS with lipid A mostly responsible for toxicity
• O antigen do not cause disease by themselves

• c3a and c5a anaphylaxis reaction
• low bp: hypotension/shock

LOS

• Lipooligosaccharide

Exotoxins

Protein synthesis inhibitors

.

ADP Ribosylation

C. Diphtheria

• ADP-ribose added to EF-2 from NAD that makes EF-2 nonfunctional

Pseudomonas aeruginosa

Shigella

EHEC

Fluid Secretion Toxins

ETEC

LT:

ST:

Bacillus Anthrax

Anthrax ulcers with necrotic center and edema borders:

Phagocytosis Inhibitors

Neurotoxins

Cell membrane lysis toxin

C. perfringens

Strep pyogenes

• strep throat, rheumatic fever, glomerulonephritis

• C. diphtheria: virus delivers DNA to bacteria

Superantigens

• directly connects MHC to TCR and activates multiple T cells.
• Result: vasodilation and shock

TSST

• Sepsis does not have diarrhea and desquamation..