02 Purine

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• direct synthesis from building blocks
• salvage: breaks down DNA, salvage bases

• amino: amine group

Purine Synthesis

• A and G: nitrogen group

• adding phosphate groups to 1 C

• THF from vitamin folate, important for thymidine and purine
• folate: single carbon donor

Salvage

• salvaging pathway inhibited

Excretion

• under excretion: furosemide
• overproduction