Malaria
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Life cycle
- sporozoite infectious form
- not get sick for several weeks
- schizonts: many nuclei, ready to rupture
- in liver, hasn't reached RBC
- can see on blood smears
- cyclic fever whenever schizonts rupture
- erythrocyte cycle cause of fever pattern
Symptoms
Vivax
- primaquine the one drug that treats vivax, doesn't treat active cell
Malariae
Falciparum
Diagnosis
Protection
- Duffy antigen on RBC necessary for infection
Treatment
- plasmodium converts Hgb heme to nontoxic form using heme polymerase
- mefloquine prophylaxis for travelers. Very vivid dreams SE
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